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Homeopatia Funciona?


A grande polêmica em torno da eficácia da homeopatia se apoia no discurso daqueles que alegam não existirem estudos específicos sobre sua eficácia. Aqui vão alguns estudos Clínicos e Biológicos que tratam do assunto. Essa é uma coletânea antiga que fiz.

Atualmente há muitos outros mais em revistas indexadas. Basta fazer uma pesquisa. Então vamos lá:

ARTIGOS PUBLICADOS QUE COMPROVAM AS ATIVIDADES CLINICAS E LABORATORIAIS DA HOMEOPATIA

  1. PESQUISA CLINICA

  • Paterson J., Report on mustard gás experiments, British Homeopathic Journal, 1943; 33: 1-12

  • Paterson J.,Report on the gás experiments, Journal of American Institut of Homeopathy, 1944; 37 : 47-50, 88-92

  • Gibson R G, Gibson S, MacNeill A, Gray G, Carson D, Buchanan W, Salicylates and Homeopathy in rheumatoid arthritis: preliminary observations, British Journal of Clinical Pharmacology, 1978 ; 6, 391-395

  • Huston G, Salicylates and Homeopathy, British Journal of Clinical Pharmacology, 1979; 7: 529-530

  • Gibson R, Gibson S, MacNeill A, Buchanan W, the place for non-pharmaceutical therapy in chronic rheumatoid arthritis: a critical study of homeopathy, British Homeopathic Journal, 1980; 69, 121-133

  • Owen R, Ives G, The mustard gás experiments of the British Homeopathic Society 1942,Proceedings of the XXXV International Homeopathic Congress, 1982; 258-269

  • Pr Casanova et Drs Basquin, Mangenay, Pacotte, Questel, Syndrome grippal et doublé insu, Tônus, 1984 : 814 : 8

  • Reilly D, Taylor M, Potent placebo or potency ? A proposed study model with initial findings using homeopathically prepared polens in hayfever, British Homeopathic Journal, 1985 ; 74 : 65-75

  • Reilly D, Taylor M, Mc Sharry C, Aitchison T, Is homeopathy a placebo reponse ? Controlled trial of homeopathic potency, with Pollen in hayfever as model, The Lancet, 1986 ; 881-886

  • Fisher P, An experimental doublé-blind clinical trial method in homeopathy. Use of a limited range of remedies to treat fibrosits, British Homeopathic Journal, 1986 ; 75, 142-147

  • O´Keefe D , Is homeopathy a placebo response ? The lancet, 1986 ; ii : 29 : 1106-1107

  • Ferley J, Zmirou D, D´Adhemar D, Balducci F, A controlled evaluation of a homeopathic preparation in treatement of influenza-like syndromes, British Journal of Clinical Pharmacology, 1989; 27 : 329-335

  • Fisher P, Greenwood A, Huskinsson E, Turner P, Bolon P, Effect of homeopathic treatment on fibrositis ( prymary fribromyalgia), British Medical Journal; 1989 ; 299 : 365-366

  • Quadruple-blind, The Lancet, 1989 ; avril, 22 : 914

  • Kleijnen J, Knipschild P, Riet G, Clinical trials of homeopathy, British Medical Journal, 1991 ; 302 : 316-323

  • Fisher P, Greenwood A, Huskisson E, Turner P, Belon P, ; Traitement homeopathique de la fibromyalgie primaire : a propôs de deux essais cliniques em doublé insu, Homeopathie Française, 1991 ; 79 , n° 4 , 15-22

  • Brigo B, Serpelloni G, Homeopathic treatement of migraines : a randomized doublé-blind study of sixty cases ( homeopathy X placebo), Berl. J. Res. Hom. , 1991 ; 1 ; 98-106

  • Jacobs J, Jimenez L, Gloyd S, Carares F, Gaitan M, Crothers D, Homeopathic treatement of acute childhood diarrhea, British Homeopathic Journal, 1993 ; 82 : 83-86

  • De Lange de Klerk E, Blommers J, Kuik D., Bezemer P, Feenstra L, Effect of homeopathic medicines on daily burden of symptons in children with recurrent upper respiratory tract infections, British Medical Journal , 1994 ; 309(6965) : 1329-32

  • Jacobs J, Jimenez L, Gloyd S, Galé J, Crothers D, Treatement of acute childhood diarrhea with homeopathic medicine : a randomized clinical trial in Nicarágua, Pediatrics, 1994 ; vol 93, 5 : 719-725

  • Reilly D, Taylor M, Beattie N, Campbell J, Mc Sharry C, Aitchison T, Carter R, Stevenson R. , Is evidence for homeopathy reproductible? , The Lancet , 1994; 344 : 1601-1606

  • Bissuel F, Cotte L, Crapanne J, Rougier P, Schlienger I, Trepo C, Trimethropim-sulphamethoxazole rechallenge in 20 previously allergic HIV-infected patients after homeopathic desensibilisation , AIDS , 1995 ; 9 , n° 4 , 407-408

  • Boissel J, Cucherat M, Haugh M, Gauthier E, Overview of data from homeopathic medicine trials : report on the efficacy of homeopathic interventions over no treatement or placebo, Report to the European Commission, D.G. XIII, 1996

  • Rothwell P, Aulas J, Kahn M, Gagnon R, Van Duijn P, Happle R, Letters to the Editor : Is evidencefor homeopathy reproductible? , The Lancet, 1995 ; 345 , 251-252

  • Conforti A, Bertani S, Metelmann H, Chirumbolo S, Luissignoli S, Bellavite P, Experimental studies on the anti-inflamatory activity of a homeopathic preparation, Biomed. Ther. , 1997 ; 15(1) : 28-31

  • Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges V, Jonas W, , Are the clinical effectes of homeopathy placebo effects? A meta-analysis of placebo-controlled trials, The Lancet , 1997 ; 350 , 9081 : 834-843

  • Matusiewicz R, The homeopathic treatement of corticosteroid-dependent asthma. A doublé-blind, placebo-controlled study, Biomed. Ther. , 1997 ; 15(4) : 117-122

  • Papp R, Schubaack G, Beck E, Burkard G, Bengel J, Lehrl S, Belon P, Oscilococcinum° in patients with influenza-like syndromes : a placebo-contrlled double-blind evaluation, British Homeopathic Journal , 1998 ; 87 : 69-76

  • Albrecht H, Schutte A, Homeopathy versus antibiotics in metaphylaxis of infections diseases : a clinical study in pig fattening and its significance to consumers , Altern. Ther. Health. Méd. , 1999 ; 5(5) : 64-8

  • Handshuh J, Debray M, Modification of cutâneos blood flow by skin application of homeopathic anti-inflamatory gels , S.T.P. pharma sciences , 1999 ; 9 (2) : 219-222

  • Jonas W, , Do homeopathic nosodes protect against infection ? Na experimental test. Altern. Ther. Health. Méd. , 1999 ,; 5 (5) : 36-40

  • Lussignoli S, Bertani S, Metelmann H, Bellavite P, Conforti A, Effect of traumeel S, a homeopathic formulation on blood-induced inflamation in rats, Complement Ther. Méd. ;1999 ; 7 (4) :225-30

  • Weiser M, Gegenheimer L, Klein P, A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatement of seasonal allergic rhinitis, ; Forsch Komplementarmed, 1999 ; 6 : 142-148

  • Aabel S., No beneficial effect of isopathic prophylactic treatment for birch pollen allergy during a low-pollen season : a double-blind, placebo-controlled clinical trial of homeopathic Betula 30c, British Homeopathic Journal, 2000 ; 89(4) : 169-73.

  • Aabel S., Laerum E., Dolvik S., Djupesland P., Is homeopathic ‘immunotherapy’ effective? A double-blind, placebo-controlled trial with the isopathic remedy Betula 30c for patients with birch pollen allergy, British Homeopathic Journal, 2000; 89(4) : 161-8.

  • Balzarini A., Felisi E., Martini A., De Conno F., Efficacy of homeopathic treatment of skin reactions during radiotherapy for breast cancer ; a randomized , double-blind clinical trial, British Homeopathic Journal, 2000 ; 89(1) : 8-12.

  • Jacobs J., Jimenez M., Malthouse S., Chapman E., Crothers D., Masuk M., Jonas W., Homeopathic treatment of acute childhood diarrhea : results from a clinical trial in Nepal., J. Altern. Complement. Med., 2000 ; 6(2) : 131-9.

  • Taylor M.A., Reilly D., Llewellyn-Jones R.H., McSharry C. et Aitchison T.C., Randomised controlled trial of homeopathy versus placebo in perennial rhinitis with overview of four trial series, British Homeopathic Journal, 2000 ; 321 : 471-476.

  • Aabel S., Prophylactic and acute treatment with homeopathic medicine, Betula 30c for birch pollen allergy : a double-blind, randomized, placebo-controlled study of consistency of VAS responses, British Homeopathic Journal, 2001 ; 90(2) : 73-8.

  • Berrebi A., Parant O., Ferval F., Thene M., Ayoubi J.M., Connan L., Belon P., Traitment de la douleur de la montée laiteuse non souhaitée par homéopathie dans le post-partum immédiat, J. Gynecol. Obstet. Biol. Reprod. (Paris), 2001 ; 30(4) : 353-7.

  • Glatthaar-Saalmuller B., Fallier-Becker P., Antiviral action of Euphorbium compositum and its components, Forsch Komplementarmed Klass Naturheilkd, 2001 ; 8(4) : 207-12.

  • Jacobs J., Springer D.A., Crothers D., Homeopathic treatment of acute otitis media in children : a preliminary randomized placebo-controlled trial, Pediatr. Infect. Dis. J., 2001 ; 20(2) : 177-83.

  • Oberbaum M., Yaniv I., Ben-Gal Y., Stein J., Ben- Zvi N., Freedman L.S., Branski D., A randomized, controlled clinical trial of the homeopathic medication Traumeel S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation, Cancer, 2001 ; 92(3) : 684-90.

  • Lewith G.T., Watkins A.D., Hyland M.E., Shaw S., Broomfield J.A., Dolan G., Holgate S.T., Use of ultramolecular potencies of allergento treat ashmatic people to house dust mite : a double-blind randomized controlled clinical trial, British Homeopathic Journal, 2002 ; 324(7336) : 520.

  1. PESQUISA BIOLÓGICA

  • Poitevin B. , Aubin M. , Benveniste J. , Approche d´une analyse quantitative de l`effect d´Apis

Mellifica sur la degranulation des basophiles humains in vitro, Innov. Tech. Biol. Med. Vol 7

N° 1, 1986

  • Poitevin B., Davenas E., Benveniste J. , In vitro immunological degranulation of human

Basophils is modulated by lung histamine and Apis mellifica, Brits. Journ. Clin. Pharmac.

25 , 439-444, 1988

  • Doutremepuich C., Pailley D., Anne M.C., De Seze O., Paccalin J., Quilichini R., Template bleeding time after ingestion of ultra low dosages of acetyl salycilic acid in healthy subjects, Preliminary study, Thromb. Res. Suppl., 1987 ; 48(4) : 501-4.

  • Doutremepuich C., De Seze O., Anne M.C., Hariveau E., Quilichini R., Platelet aggregation on whole blood after administration of ultra low dosage acetylsalicylic acid in healthy volunteers, Thromb. Res. Suppl., 1987 ; 47(3) : 373-7.

  • Doutremepuich C., Pailley D., De Seze O., Anne M.C., Paccalin J., Quilichini R., Variation of bleeding time after administration of acetylsalicylic acid at different doses in the healthy volunteer, Ann. Pharm. Fr., 1998 ; 46(1) : 35-9.

  • Doutremepuich C., De Seze O., Le Roy D., Lalanne M.C., Anne M.C., Aspirin at very ultra low dosage in healthy volunteers : effects on bleeding time, platelet aggregation and coagulation, Haemostasis, 1990 ; 20(2) : 99-105.

  • Lalanne M.C., Doutremepuich C., De Seze O., Belon P., What is the effect of acetylsalicylic acid at ultra low dose on interaction platelets/vessel wall?, Thromb. Res. Suppl., 1990 ; 60(3) : 231-6.

  • Lalanne M.C., De Seze O., Doutremepuich C., Belon P., Could proteolytic enzyme modulate the interaction platelets/ vessel wall in presence of ASA at ultra low doses?, Throm. Res. Suppl., 1991 ; 63(4) : 419-26.

  • Lalanne M.C., Ramboer I., De Seze O., Doutremepuich C., In vitro platelets/ endothelial cells interactions in presence of acetylsalicylic acid at various dosages, Thromb. Res. , 1992 ; 65(1) : 33-43.

  • Vesvres M.H., Doutremepuich F., Lalanne M.C., Doutremepuich C., Effects of aspirin on embolization in an arterial model of laser-induced thrombus formation, Haemostasis, 1993 ; 23(1) : 8-12.

  • Doutremepuich C., Aguejouf O., Pintingny D., Sertillanges M.N., De Seze O., Thrombogenic properties of ultra-low-dose of acetylsalicylic acid in a vessel model of laser-induced thrombus formation, Thromb. Res., 1994 ; 76(2) : 225-9.

  • Doutremepuich C., Aguejouf O., Belon P., Effects of ultra-low-doseaspirin on embolization in a model of laser-induced thrombus formation, Semin. Thromb. Hemost., 1996 ; 22 Suppl. 1; 67-70.

  • Aguejouf O., Belougne-Malfatti E., Doutremepuich F., Belon P., Doutremepuich C., Thromboembolic complications several days after a single-dose administration of aspirin, Thromb. Res., 1998 ; 89(3) : 123-7.

  • Belougne-Malfatti E., Aguejouf O., Doutremepuich F., Belon P., Doutremepuich C., Combination of two doses of acetylsalicylic acid : experimental study of arterial thrombosis, Thromb. Res., 1998 ; 90(5) : 215-21.

  • Aguejouf O., Malfatti E., Belon P., Doutremepuich C., Effects of acetylsalicylic acid acid therapy on an experimental thrombosis induced by laser beam, Thromb. Res., 2000 ; 99(6) : 595-602.

  • Aguejouf O., Malfatti E., Belon P., Doutremepuich C., Time related neutralization of two doses acetylsalicylic acid, Thromb. Res., 317-23.

  • Bonamin L.V., Martinho K.S., Nina A. L., Cavigla F., Do Rio R. G., Very high dilutions of dexamethasone inhibit its pharmacological effects in vivo, British Homeopathic Journal, 2001 ; 90(4) : 198-203.

  • Chang M.P., Bramhall J., Graves S., Bonavida B., Wisnieski B.J., Internucleosonal DNA cleavage precedes diphteris toxin-induced cytosine. Evidence that cell lysis is not a simple consequence of translation inhibition, J. Biol. Chemestry, 1989 ; 264 : 15261-67.

  • Bonavida B., Safrit J., Tsuchitani T., Zighelboim J., Overcoming tumor cell drug resistance by low doses of recombinant tumor necrosis factor and drug, In : Ultra Low Doses, C. Doutremepuich, ed. Taylor & Francis, 1991, Washington D.C., 27-43.

  • Morimoto H., Safrit J.T., Bonavida B., Synergistic effect of tumor necrosis factor-µ and diphteria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines, J. Immunol., 1991, 147 : 2609-2616.

  • Safrit J.T., Tsuchitani T., Berek J., Zighelboim J., Bonavida B., Overcoming drug resistance by synergistic activity of drug and tumor necrosis factor, In : New frontiers in the therapy of malignancies. From biological approaches to clinical studies, Serono Symposium Rev., No. 25. Mantovani G., Bonavida B., Del Giacco G.S., Granger G.A., Kirkwood J.M., eds., Published by Ares Serono Symposia via Ravencia 8, Rome, Italy, 1991, 11-17.

  • Tsuchitani T., Zighelboim J., Berek J., Bonavida B., Potentiation of cytotoxicity against human ovarian cell-lines with combinations of subtoxic concentrations of tumor necrosis factor and adriamycin or cys-platinum, J. Cell. Pharmacol., 1991, 2 : 32-40.

  • Morimoto H., Bonavida B., Diphteria-toxin and Pseudomonas. A toxin-mediated apoptosis : ADP-ribosylation of EF-2 is required for DNA fragmentation and cell lysis and synergy with Tumor Necrosis Factor-µ, J. Immunol., 1992, 49 : 2089-2094.

  • Safrit J.T., Berek J., Bonavida B., Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-µ) and doxorubicin. Failure of the combination to modulate the MDR phenotype, Gynecol. Oncol., 1992, 48 : 214-220.

  • Safrit J.T., Bonavida B., Sensitivity of resistant human tumor cell lines to TNF and adriamycin used in combination : correlation between down-regulation of TNF-mRNA induction and overcoming resistance, Cancer Res., 1992, 52 : 6630-6637.

  • Morimoto H., Yonehara S., Bonavida B., Overcoming tumor necrosis and drug resistance of human tumor cell lines by combination treatment with anti-Fas antibody and drugs or toxins, Cancer Res., 1993, 53 : 2591-2596.

  • Safrit J.T., Belldregun A., Bonavida B., Sensitivity of human renal cell carcinoma lines to TNF, adriamycin and combination : role of TNF-mRNA induction in overcoming resistance, J. Urology, 1993, 149 : 1202-1208.

  • Morimoto H., Bonavida B., Lack of involvement of protein tyrosine kinases in synergistic cytotoxic and apoptoptic activities mediated by tumor necrosis factor and diphteria toxin (DTX) in a TNF-µ resistant ovarian carcinoma cell line, Cell Pharmacol., 1995, 2 : 147-152.

  • Mori S., Muramaki-Mori K., Jewett A., Nakamura S., Bonavida B., Resistance of AIDS-associated Kaposi’s sarcoma cells to Fas-mediated apoptosis, Cancer Res., 1996, 56 : 1874-1879.

  • Uslu R., Bonavida B., Involvment of the mithocondrion respiratory chain in the synergy achieved by treatment of human ovarian carcinoma cell lines with both tumor necrosis factor-µ and cis-diamminedichloroplatinum, American Cancer Society, 1996, 77 : 725-732.

  • Frost P., Ng C.P., Belldegrun A., Bonavida B., Immunosensitization of prostrate carcinoma cell lines for lymphocytes (CTL, TIL, LAK) – mediated apoptosis via the Fas-ligand pathway of cytotoxicity, Cell. Immunol., 1997, 180 : 70-83.

  • Linde K., Clausius N., Ramirez G., Melchart D., Eitel F., Hedges L.V., Jonas W.B., Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. The Lancet, 1997, 350 : 834-843.

  • Garban H.J., Bonavida B., Niric oxide sensitizes ovarian tumor cells to Fas-induced apoptosis, Gybecol. Oncol. 1999, 73 : 257-264.

  • Kersh E.N., Shaw A.S., Allen P.M., Fidelity of T cell activation through multistep T cell receptor zeta phosphorilation, Science, 1998, 281(5376) : 572-575.

  • Torigoe C., Inman J.K., Metzger H., An unusual mechanism for ligand antagonism, Science, 1998, 281 : 568-572.

  • Cazin J.C., Cazin M., Gaborit J.L., Chaoui A., Boiron J., Belon P., Cherruault Y., Papapanayotou C., A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilization of arsenic in the rat, Human Toxicology, 1987 ; 6 : 315-320.

  • Mitra K., Kundu S.N., Khuda Bukhsh A.R., Efficacy of a potentized homeopathic drug (Arsenicum album 30) in reducing toxic effects produced by arsenic trioxide in mice ; I. On rate of accumulation of arsenic in certain organs, Com Ther Med, 1998 ; 6 : 178-184.

  • Mitra K., Kundu S.N., Khuda Bukhsh A.R., Efficacy of a potentized homeopathic drug (Arsenicum album 30) in reducing genotoxic effects produced by arsenic trioxide in mice : III. Enzymatic changes and recovery of tissue damage in liver, Com Ther Med, 2000 ; 8 : 76-81.

  • Mitra K., Kundu S.N., Khuda Bukhsh A.R., Efficacy of a potentized homeopathic drug (Arsenicum album 30) in reducing cytotoxic effects produced by arsenic trioxide in mice : IV. Pathological changes, protein profilkes and content of DNA and TNA, Com Ther Med, 2000 ; 8 :157-165.

  • Khuda Bukhsh A.R., Efficacy of a potentized homeopathic drug in combating arsenic poisoning a suggestive scientific probe, in Manna G.K. & Roy S.C., editors, Perspectives of cytology an genetics, AICCG Publishers, 2001, 10 : 231-239.

  • Mallick P., Chakrabarti (Mallick) J., Guha B., Khuda Bukhsh A.R., Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum album, on arsenic-induced toxicity in mice, BMC Compl & Altern Med, 2003, 3 : 7-16.

  • Rey L.R., Low-temperature thermoluminescence, Nature, 1998, 391 : 418.

  • Mishima O., Stanley H.E., The relationship between liquid, supercooled and glassy water, Nature, 1998, 396 : 329-335.

  • Rey L.R., Thermoluminescence de la glace, C.R. Physique, 2000, 1 : 107-110.

  • Rey L.R., Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride, Physica A, 2003, 323 : 67-74.

  • Teixeira J., L’eau est-elle schizophrène ?, La Recherche, 2003 , 363 : 42-43.

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